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Detecting Alzheimer’s Disease: Research Aims for Earlier Diagnosis

NIH | Nov 11, 2014, midnight

Do you ever forget where you put your car keys or what you were supposed to pick up at the grocery store? You might worry that these memory lapses, or “senior moments,” could be an early sign of Alzheimer’s disease (AD), an irreversible brain illness. AD is the most common cause of dementia, which involves memory loss, loss of the ability to solve problems, personality changes and behavioral problems severe enough to interfere with normal activities and relationships.

If you’re concerned about changes in what you can and can’t remember, a neurologist or other expert in brain function can test you to find out whether these changes are normal or an early sign of AD. However, doctors can only diagnose AD once symptoms develop. For researchers hoping to slow the progression of AD or prevent it altogether, these clinical tests come very late in the game.

What if there were ways to detect AD well before the signs of memory loss appeared in everyday life? Earlier diagnosis would allow researchers to test possible drugs more quickly for better and earlier treatments.

“There are a number of new drugs under development that we hope will interfere with the progression of Alzheimer’s,” notes Dr. Susan Molchan of the AD Clinical Trials Program at NIH’s National Institute on Aging (NIA). “Ultimately, what we want to be able to do is to test and provide medications that can preserve memory for people at risk.”

But doctors often can’t tell who those people are until the disease has already developed. Several lines of research funded by NIH are now aiming to uncover AD as early in the disease process as possible.

More than 90% of AD cases develop in people older than 65. AD and dementia, however, are not a normal part of aging.

AD comes about when nerve cells in the brain stop working, lose connections with other nerve cells and die. If you picture a brain as a giant network of highways that relay information, it’s as if some cars break down and stop working. Even cars that still work eventually get caught in traffic jams so they can’t get to their destinations.

The first breakdowns in AD occur in those parts of the brain that control memory. As these nerve cells stop working correctly, short-term memory fails and the ability to do familiar tasks can begin to decline. Damage follows in those parts of the brain responsible for language and reasoning. Over time, even more areas become entangled, leading to behavior and personality changes as well as problems with decision-making and thinking. In the end, a person with AD is bedridden and unable to recognize even close family members. It is a slow process, usually lasting 8-10 years or more.

Researchers have discovered some of the key culprits behind AD. Protein fragments called beta-amyloid form clumps in the spaces between the brain’s nerve cells. Researchers think these “plaques” may function like road blocks that keep signals from passing between nerve cells. Another protein called tau forms “tangles,” masses of twisted protein threads, inside nerve cells. These tangles, researchers believe, affect communication between nerve cells and eventually cause the cells to die. As more and more cells die, those brain areas begin to shrink.

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